Controlling the Brain with Optogenetics

Controlling the Brain with Optogenetics

Imagine controlling neuronal activity with nothing but a miniature flashlight. Shine the light on a set of neurons and they fire up, sending action potentials across the brain and back. Turn the light off and they’re back to resting state. Though perhaps a bit of an exaggeration, this idea basically captures the essence of optogenetics, which in more scientific terms refers to the use of light responsive “opsin” proteins to produce genetically modified neurons. 

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Virtual Reality as a Tool to Treat and Diagnose PTSD

Virtual Reality as a Tool to Treat and Diagnose PTSD

Post-traumatic stress disorder (PTSD) is more prevalent than ever and has created a significant behavioral healthcare challenge. PTSD is a psychiatric disorder that can occur in individuals who have experienced a traumatic event such as war combat, sexual assault, or a natural disaster. In an era following multiple wars and extremely high rates of reported sexual assault, our healthcare system is in need of a more effective method to diagnose and treat PTSD.

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Microglia and Neurotoxicity

Microglia and Neurotoxicity

“Any man who reads too much and uses his own brain too little falls into lazy habits of thinking”- Albert Einstein [6]. Einstein perfectly sums up the importance of the brain for cognitive functioning throughout our daily lives. Effective cognition results from an efficient functioning of the various molecular pathways in our brain. Let us focus on one molecular aspect of the brain- Microglia. Microglia are types of glial cells, which act as macrophages and are present throughout the Central Nervous System (CNS). These non-neuronal cells are responsible for the protection and support of neural activities. They are widely distributed throughout the brain and spinal cord and make up about 5-20% of glial cells within the CNS [1]. The two noteworthy features of the microglia are CNS maintenance and immune defense. An appropriate balance of microglial concentration is required to promote homeostasis of the CNS [1].

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Dimethyl Sulfoxide (DMSO) for the Treatment of Intracranial Cerebrospinal Fluid Pressure

Dimethyl Sulfoxide (DMSO) for the Treatment of Intracranial Cerebrospinal Fluid Pressure

Dimethyl Sulfoxide (DMSO) was discovered in the 1950’s to be used as a useful treatment for a myriad of conditions. First discovered in its industrial applications, this essay will examine its properties and promise for treating various ailments including intracranial hypertension. Being a small molecule, slightly larger than water, DMSO penetrates into the skin almost immediately, making it useful as an agent to improve the transport of drugs deeper into targeted tissues.

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The Future of Football: Chronic Traumatic Encephalopathy in Athletes

The Future of Football: Chronic Traumatic Encephalopathy in Athletes

Football is the great American pastime. Large numbers of athletes at the youth, high school, and college levels participate in organized football. At the professional level, the sport generates a huge amount of media attention, interest, and revenue. In recent years, however, warnings about the brain injury risks inherent in football have come from retired players, coaches, and medical professionals, along with increased public awareness about the danger of repeated head trauma.

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Chronic Traumatic Encephalopathy (CTE)

Chronic Traumatic Encephalopathy (CTE)

Every 15 seconds, someone suffers from a traumatic brain injury, due to car accidents, contact sports, or simply getting hit in the head. Although most people survive, concussions should not be taken lightly, because they impair neurological function. The effects of concussions are cumulative, thus, repeated head injuries can result in chronic traumatic encephalopathy (CTE).

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Mirror Neurons

Mirror Neurons

Mirror neurons have been referred to as the "most hyped concept in Neuroscience". Mirror neurons were first discovered in the 1990s by chance when a team of Italian scientists was studying the mechanisms behind certain actions and recording neuronal control of motor activity in macaque monkeys. These scientists saw that the same cells were activated when a monkey observed an action as when the monkey performed the same action itself. This fascinating discovery has allowed us to expand on our ambitions of a greater understanding and insight to certain behaviors.

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