Join our Efforts!
Physicians
We help physicians set up HIPAA compliant data collection for Patient Reported Outcomes (PROs), participate as an investigator or sub-investigator for a current study, or create and design an original research study.
Patients
We match patients seeking innovative methods to promote their own healing to clinical trials employing research-backed technology and innovations.
Companies
We connect with companies that are interested in running clinical trials and gather high quality data to validate the safety and efficacy of their products. We are a site for IDEs and post-market trials for biologics and devices.
Our Research
Current
Our ongoing commitment to functional research focuses on evaluating the safety and efficacy of emerging technologies in spinal surgery through both prospective and retrospective clinical studies. We aim to identify the devices and techniques that most effectively improve patient outcomes, using validated clinical metrics and radiographic imaging.
As a clinical research hub for multiple private practices, we seek to harness the rich data available across each site to advance care through the development of new surgical technologies, spinal implants, biologics, and patient-centered interventions. We are currently recruiting and enrolling patients in the following active studies. More information is available on ClinicalTrials.gov.
BAGUERA® C Cervical Disc Replacement Clinical Trial
A multi-center study evaluating the safety and effectiveness of the BAGUERA® C artificial cervical disc.Synergy Disc vs. ACDF in Two-Level Symptomatic Cervical DDD
A historically controlled pivotal trial comparing the Synergy Disc to anterior cervical discectomy and fusion.M6-C™ Artificial Cervical Disc Two-Level IDE Pivotal Study
Assessing outcomes of the M6-C™ cervical disc in patients with two-level cervical disc disease.Decompression With or Without Interlaminar Stabilization Device
A prospective study examining treatment outcomes for degenerative lumbar spinal stenosis.Effectiveness of a Therapeutic VR Intervention for Perioperative Optimization in Spine Surgery
A randomized prospective trial in collaboration with InnerState, Inc.TOPS™ System Pivotal Study
A pivotal trial evaluating whether the Premia Spine TOPS™ System improves outcomes over TLIF in patients with lumbar spinal stenosis, Grade 1 spondylolisthesis, and facet capsule pathology.Combination Study: TOPS™ System + ProdiscⓇ L Lumbar Disc Replacement
A clinical study investigating the safety and effectiveness of combining the Prodisc L total disc replacement with the TOPS™ System in patients with both disc and facet pathology at the same level (L3–L5).Mindfulness Meditation for Acute on Chronic Postoperative Pain in Outpatient Spine Surgery
A prospective clinical trial exploring the role of mindfulness meditation in managing post-surgical pain in spine surgery patients.
We are also currently conducting the following retrospective studies and seeking physicians with relevant data to help expand our analysis.
Hybrid Constructs in Cervical Spine Surgery
Retrospective analysis evaluating outcomes of hybrid constructs that combine fusion and motion-preserving technologies in the cervical spine.Premia Spine TOPS™ System in the Ambulatory Surgery Center (ASC) Setting
Retrospective review of safety, effectiveness, and patient outcomes using the TOPS™ device in outpatient/ASC environments.
Future Directions
Through collaborations with other research organizations, community partners, and small businesses, we are pursuing investigations into the following studies. We encourage and welcome interested partners who would like to join and contribute to our efforts to send inquiry emails to research@inifoundation.org.
Global Spinal Arthroplasty Registry
A developing AI-driven national database to aggregate and analyze operative data from spinal arthroplasty procedures.
Four Horsemen of the Nervous System
Exploring the major drivers of Nervous System dysfunction: Pain, Dementia, Depression, and Trauma— to guide future therapies that promote resilience and long-term brain health.
Psychedelic Research
Exploring the therapeutic potential and clinical protocols of ketamine and other psychedelics for treating chronic pain, depression, and perioperative care.
Proudly Partnering with Mystic Health
We are exploring collaborative research at the intersection of neuroscience and mental health through a partnership with Mystic Health and Dr. Houman Farzin, to develop studies on the therapeutic potential of psychedelic-assisted care in palliative and neurological settings.
Past
Our past publications and presentations are available and open access to all who are interested in our work. Please email us to request access to full text:
Ament JD, Petros J, Gardner C, Vokshoor A. The First Grade III Lumbar Spondylolisthesis Treated With the Novel 360° Artificial Disc/Artificial Facet Replacement Solution. Int J Spine Surg. 2025 Jun 26:8769. doi: 10.14444/8769. Epub ahead of print. PMID: 40571488.
Ament, J.D., Petros, J.A., Zabehi, T., Yee, R., J. Patrick Johnson and Amir Vokshoor (2024). A Prospective Study of Lumbar Facet Arthroplasty in the Treatment of Degenerative Spondylolisthesis and Stenosis: Cost-effective Assessment from the Total Posterior Spine (TOPSTM) System IDE Study: 2-Year Model Revision and Sensitivity Analyses Based on 305 Subjects. The Spine Journal. doi:https://doi.org/10.1016/j.spinee.2024.01.004.
Vokshoor, A., Jajj, H., Grunwald, T. et al. Posterior cervical congenital dermal sinus tract: case report and review of literature. Spinal Cord Series and Cases 9, 40 (2023). https://doi.org/10.1038/s41394-023-00575-5
Two-Year Retrospective Bayesian Assessment of Cervical Artificial Disc Replacement Failure Factors. Amir Vokshoor, M.D., Vance Matthews, B.A., Sophia Mostowy, B.A., & Johny Tran, B.A., Western Neurosurgical Society, Scottsdale, AZ, November 2019.
(Also Society of Minimally Invasive Spine Surgery, Las Vegas, NV, November 2019 - Presented by Hyun Bae, M.D.)
Retrospective Analysis of Mesenchymal Stem Cell Allograft in Integrated Interbody Cervical Devices for One or More Level ACDF Procedures. Amir Vokshoor, M.D. & Johny Tran, B.A., Western Neurosurgical Society, Banff, Canada, September 2017.
Evaluation of Interspinous Fusion in Minimally Invasive Lumbar Surgery Amir Vokshoor, M.D., Arian Esmaili, B.S., & Sanjay Khurana, M.D., 2012.
Radiographic Evaluation of Fusion and Clinical Outcomes in Minimally Invasive Lumbar Surgery using Spinous Process Fixation. Amir Vokshoor, M.D., Arian Esmaili, B.S., Sanjay Khurana, M.D., Dean Wilson, PA-C, & Peter Filsinger, M.D., Western Neurosurgical Society, 2012.
We were a clinical research site for the following studies that have recently completed enrollment and data collection. More information can be found about each trial on ClinicalTrials.gov:
Safety and Efficacy of Pulsed Electromagnetic Fields as an Adjunct to Enhance Union in Conservatively Treated Type II Fractures of the Odontoid Process
Prospective, Multi-Center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using Synthetic Bioactive Glass Morsels
Prospective Clinical Evaluation of Standalone Cervical Interbody Fusion Device
Prospective Clinical and Radiographic Evaluation of PLIF using 3D-printed Titanium Lumbar Cage
If you are interested in our research...
Please connect with us! We would love to partner with you.
